Clinical characteristics and risk factors analysis for the recurrence of pelvic endodermal sinus tumors

This study investigated the clinicopathological characteristics and factors influencing recurrence of pelvic endodermal sinus tumor (PEST). 54 cases were retrospectively analyzed from at Zhejiang Cancer Hospital. Progression-free survival (PFS) related on disease evaluated. Six patients had extragonadal tumor, four histological features (EST) combined with embryonal carcinoma (EC). 39 underwent fertility-preserving surgery, 18 a childbearing history, eight residual after initial treatment as surgery or chemotherapy. 26 diameter more than 15 cm, 30 serum αfetoprotein (AFP) level greater 10,000 ng/mL before management. The median follow-up was 47.5 months (range, 14–212 months). During follow-up, experience recurrence, rate 27.8% 5-year PFS 61.1%. In univariate analysis, FIGO (International Federation Gynecology Obstetrics) stage (stage III–IV vs. I–II; hazard ratio (HR) = 9.73, p < 0.001), (yes no for first surgery; HR 4.86, (EST EC EST; 4.08, 0.017), use platinum-based chemotherapy (courses ≥3 courses <3; 0.19, 0.004) independent recurrence. multivariate only an risk factor 6.92, 0.02). Stage is prognostic PEST. aim to maximally debulk all grossly visible post-operative should include sufficient dose full course chemotherapy, which may reduce rate. Maybe some gene expression that could be associate